Premier Glucose Manager™ by Premier Research Labs delivers a comprehensive, dual-mechanism approach to glycemic and metabolic support using two clinically validated ingredients at their scientifically substantiated doses.*
This advanced practitioner-grade formula pairs GlucoVantage® Dihydroberberine (100 mg) with Reducose® Mulberry Leaf Extract (250 mg, standardized to 12.5 mg DNJ) to address glucose regulation at both the intestinal and cellular levels, supporting balanced blood sugar responses across the full glycemic cycle.*
Unlike conventional glucose formulas that target only one pathway, Glucose Manager™ supports both carbohydrate digestion and cellular glucose utilization, offering complete metabolic coverage before and after meals.*
Why Glucose Manager™ Works Differently
Most glucose support supplements focus on either slowing carbohydrate absorption or improving insulin sensitivity. Glucose Manager™ uniquely combines both strategies in a single formula, helping to moderate post-meal glucose excursions while enhancing cellular energy metabolism and insulin signaling.*
This professional-grade formulation features two clinically-validated ingredients, each supported by human clinical research and delivered at evidence-based doses for reliable, repeatable results.*
The Power of Two Premium Ingredients:
1. GlucoVantage® Dihydroberberine (100 mg per capsule)
GlucoVantage® represents a next-generation advancement in berberine supplementation. As a hydrogenated derivative of berberine, dihydroberberine (DHB) delivers up to 5× greater bioavailability than standard berberine, allowing for enhanced effectiveness at lower doses and improved tolerability.*
How It Works:
DHB activates AMPK, often referred to as the body’s “master metabolic switch.” This activation supports insulin sensitivity, promotes healthy cellular glucose uptake, and enhances mitochondrial energy production in muscle and liver tissue.* With a sustained half-life of approximately 4–6 hours, DHB provides extended metabolic support throughout the day.*
Key Benefits:
• Promotes insulin sensitivity and cellular glucose uptake*
• Supports healthy lipid metabolism and cholesterol balance*
• Enhances metabolic flexibility and mitochondrial energy production*
• More microbiome-friendly than traditional berberine*
• Supports healthy fasting glucose levels already within the normal range*
2. Reducose® Mulberry Leaf Extract (250 mg per capsule)
Reducose® is a premium mulberry leaf extract standardized to 5% 1-Deoxynojirimycin (DNJ), delivering 12.5 mg DNJ per dose—up to 50× more DNJ than typical mulberry extracts. Its efficacy is supported by more than a decade of human clinical research.*
How It Works:
DNJ naturally inhibits alpha-glucosidase enzymes in the small intestine, slowing the breakdown of complex carbohydrates into simple sugars. This action helps smooth post-meal glucose curves, reduce insulin demand, and convert high-glycemic foods into lower-glycemic equivalents.*
Key Benefits:
• Helps reduce post-meal glucose spikes by up to 40%*
• May reduce insulin response by up to 41%*
• Supports healthy blood sugar balance after carbohydrate-containing meals*
• Enhances insulin signaling pathways*
• Extracted using a pure water process with no harsh solvents*
Clean, Practitioner-Grade Formula*
No synthetic additives, harsh solvents, or unnecessary excipients.*
Rigorous Quality Testing
Verified for identity, purity, potency, and microbiological safety to ensure uncompromised practitioner-grade quality.*
Important Safety Information
If you are taking glucose-lowering medications, consult your healthcare provider before use, as this product may have additive effects. Dihydroberberine may interact with medications metabolized by CYP450 enzymes or P-glycoprotein. Not recommended during pregnancy or lactation. Keep out of reach of children.
Well tolerated at recommended doses. The enhanced bioavailability of GlucoVantage® DHB helps minimize gastrointestinal discomfort commonly associated with traditional berberine supplements.
